Tumor Infiltrating Lymphocytes
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چکیده
9 Abstract 10 11 Tumor infiltrating lymphocytes (TILs) have been recognized in various 12 cancers and may reflect a host immune response to malignant cells. TILs 13 are a heterogeneous population of various types of mononuclear cells, 14 including CD8 or CD4 + T cells and their subsets, B cells, myeloid 15 derived suppressor cells (MDSC), macrophages, and other cells. Immuno16 suppressive factors in the tumor microenvironment (TME) that inhibit 17 recruitment and function of TILs include immunosuppressive cells, 18 cytokines secreted by tumor or mesenchymal cells, and co-inhibitory 19 ligands expressed by tumor cells. Despite this complex interplay of 20 immune cells and the TME, higher TIL density is associated with 21 favorable prognosis in certain breast cancer subtypes, including HER2 22 overexpressing cancers, and “triple negative” cancers that do not express 23 the estrogen and progesterone receptors or overexpress HER2. TILs 24 infiltrating the tumor stroma (sTILs) are associated with higher rates of 25 complete pathologic response to neoadjuvant chemotherapy, decreased 26 recurrence and improved survival in early stage triple negative and 27 HER2-positive breast cancer treated with adjuvant systemic therapy. An 28 international working group has published guidelines on reporting TILs in 29 pathology specimens. In this chapter we review the composition of TILs, 30 mechanisms of immune evasion, recommendations for TILs measurement, Murali Janakiram and Hina Khan are contributed equally to this work. M. Janakiram H. Khan X. Zang J. A. Sparano (&) Departments of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA e-mail: [email protected] M. Janakiram H. Khan X. Zang J.A. Sparano Departments of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA S. Fineberg Departments of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA M. Janakiram X. Zang Departments of Microbiology and Immunology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA Layout: T4_Grey Book ID: 331091_1_En Book ISBN: 978-3-319-41759-2 Chapter No.: 12 Date: 28-8-2016 Time: 10:10 am Page: 1/20
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تاریخ انتشار 2016